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The Alex Manos Podcast

Aug 19, 2018

In this episode we discuss the two different types of PCOS - one that is the more traditional insulin resistance based type, but, we also discuss how adrenal function can play a signifiant role in the condition also. Dr. Jones shares a couple of case studies to highlight the different strategies that may need to be considered when taking a personalised approach to PCOS.

Throughout the episode we mentioned three key drivers of hormonal imbalance - inflammation, stress, and blood sugar dysregulation, and, as a result of this we emphasise the role that lifestyle interventions play in improving symptoms including diet, exercise, stress management and sleep.

In regards to diet, there is a general trend in the research for a low carb diet for PCOS being most effective. One study, found that a lower carb diet (41:19:40% energy from CHO:protein:fat) compared to a higher carb diet, that was also matched for calorie intake, resulted in preferential loss of fat mass from metabolically harmful adipose depots.

We also dive a little deeper in to the pathophysiology, or distorted physiological processes, of PCOS for our practitioners listening. Here we discuss how testosterone and oestrogen are metabolised, via the 5a and 5b pathways, and, phase 1 and phase 2 detoxidifcaion pathways respectively.

We also touch on the importance of taking a holistic approach to improving the condition - in particular we discuss the role of gut health in PCOS and an enzyme called beta-glucuronidase and how it can influence the hormonal system.